plasmid-loaded MEV - AGS©2025

MEVs (microalgae extracellular vesicles)
to deliver Human Therapeutics, Vaccines and Gene Therapies.

We harness the potential of the billion-years old natural delivery machinery from microalgae to develop medicines for devastating human diseases.

plasmid-loaded MEV - AGS©2025

MEVs (microalgae extracellular vesicles)
to deliver Human Therapeutics, Vaccines and Gene Therapies.

We harness the potential of the billion-years old natural delivery machinery from microalgae to develop medicines for devastating human diseases.

SEM image of Chlorella vulgaris, a unicellular green microalgae, extruding extracellular vesicles (MEVs). - AGS©2025

MEVs are cell-derived lipid-bilayer nanoparticles that can carry bioactive molecules. They are secreted to the extracellular environment and naturally deliver their payload to surrounding cells thus modulating their physiology and genetics.



MEVs can be loaded and accommodate a large diversity of biologically active molecules, such as RNAs (mRNAs, siRNAs, dsRNAs...), DNAs (plasmids, oligos), peptides and proteins. Loaded MEVs protect and transport their payloads, and deliver them to the appropriate cellular compartments of the recipient cells, for proper expression and processing.

Ophthalmology
- AGS©2025

Ophthalmology, by drop instillation or by suprachoroidal injection. Discover our AGS-1010 Program for the treatment of ocular neovascularization (NV).

Oral vaccines.
- AGS©2025

Orally administered, MEVs reach the GALT (gut-associated lymphoid tissue) and the spleen, and trigger a IgA-rich immune response against antigenic payloads, making the MEVs suitable for mucosal vaccination.

CNS disorders.
- AGS©2025

CNS disorders. By intranasal administration, MEVs enter the olfactory neurons present at the nasal olfactory epithelium, and from there they travel throughout the entire olfactory tract to reach multiple specific regions of the brain, making them amenable for the treatments of degenerative, neurological, and cognitive disorders.

Bowel diseases.
- AGS©2025

Bowel diseases, by oral administration. Discover our AGS-2010 Program for the treatment of IBD (inflammatory bowel diseases).

Extracellular Vesicles from Microalgae (MEV)
to deliver Human Therapeutics and Vaccines.

Microalgae Extracellular Vesicles (MEVs)
to deliver Human Therapeutics and Vaccines.

Extracellular Vesicles from Microalgae (MEV)
as Delivery Systems for Human Therapeutics and Vaccines.

As an innovative Biopharmaceutical Company, we engineer the natural machinery of billion-years-old microalgae to develop novel therapeutics and novel vaccines.

AGS THERAPEUTICS
AGS-TX

2-billion-year-old

technology, unleashed .
Extracellular Vesicles from Microalgae (MEV)
as Drug Delivery Systems for Human Therapeutics.

As a Biopharmaceutical Company, we engineer the billion-years-old natural machinery of microalgae to develop therapeutics delivered by microalgae extracellular vesicles (MEVs).

AGS THERAPEUTICS
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MEV-mediated delivery and expression of GFP-mRNA in human endothelial cells. - AGS©2025

Confocal 3D images showing the penetration of pKH26-labelled MEVs into macrophages cells and nucleus. - AGS©2025

In vivo tracking of Dir-labelled MEVs in specific regions of the brain, after intranasal administration. - AGS©2025

Internalization of fluorescent-labelled MEVs by human endothelial cells. - AGS©2025

Internalization of PKH26-labelled MEVs by GALT cells following oral administration.  AGS©2025

MEVs-mediated delivery and expression of GFP-mRNA in human hepatocytes in vitro. - AGS©2025

Electron micrograph of a MEV. - AGS©2025

Light micrograph of Chlorella vulgaris, a unicellular green microalgae. Image by Stammers Sinclair - AGS©2025