AGS Therapeutics (www.ags-tx.com) is a preclinical-stage biotech company pioneering microalgae extracellular vesicles (MEVs) as a new, universal, delivery system for innovative therapeutics. MEVs have shown to be a safe, targeted and highly versatile delivery system for innovative biologics, such as mRNA, siRNA, DNA, plasmids, and proteins for a broad range of human diseases.
AGS-M (www.ags-m.com), the contract development and manufacturing organization (CDMO) subsidiary, produces the MEV needed to support preclinical and clinical development of MEV-based product pipelines from AGS and from pharmaceutical partners of AGS. AGS’ MEVs are derived from Chlorella, a two-billion-year-old single-cell algae, classified as GRAS, and used for decades as a food supplement.
With a strong IP position and an experienced and dedicated team onboard, AGS works on proprietary technology platforms including microalgae cell engineering, biomolecule design, biopharmaceutical product development in vitro and in vivo, MEVs manufacturing at lab and pre-industrial scale, MEVs bio-analytics and characterization.
We are seeking to hire motivated professionals with experience in life sciences, engineering, and biotechnology to join the team and help us build and lead a novel, green generation of biopharmaceuticals.
■ Provide expertise and insight to guide development of appropriate DSP for our MEVs.
■ Improve and upscale existing DSP and develop novel DSP for the purification of MEVs.
■ Develop, validate, and transfer robust analytical methods required for development and manufacturing.
■ Compile and analyze experimental data to generate process knowledge and decide on next steps.
■ Comply methods and processes to applicable GMP regulations whenever required.
■ Write development and validation reports and ensure their timely delivery.
■ Prepare and present project updates to upper management.
■ Ensure a continuous improvement within DSP development activities.
■ Responsible for activities ranging from MEVs concentration, clarification, purification, filtration, and biochemical and biophysical characterization of MEVs.
■ Develop and validate process control and standardization studies (batch-to-batch variation, batch release).
■ Perform, develop, and optimize robust, efficient, scalable strategies for improving DSP performance. Activities will include small-scale studies and pilot scale DSP studies
■ Ensure the tech transfer to AGS’ future manufacturing facility.
■ Fully comply with traceability and quality assurance procedures in place within AGS.
■ Ensure compliance of DSP protocols with applicable safety standards in relevant areas, considering laws, regulations, and directives.
■ Participate to scientific publications and to patent applications.
■ Search and analysis of scientific and technical publications to design processes and choose relevant methodology.
■ Plan, perform and supervise experiments; process and analyze experimental data; aggregate, interpret and present research results.
■ Get satisfactorily integrated in the AGS’ team.
■ Solid theoretical basis and hands-on experience in downstream processing (clarification, concentration, purification), and analytical characterization of biologicals
■ Track record in Downstream Process Development, process optimization, process integration, and process industrialization.
■ M.Sc./M.Eng. degree in biochemistry, biotechnology, bioprocess engineering or related field; or Ph.D. degree in biology, biochemistry, biotechnology, or related field.
■ 3+ years of industry track record with bioprocesses in fast-moving technology teams, preferable in a start- up environment; or 3+ years of research experience in academic and/or industry environment.
■ Highly motivated, detail-oriented and organized. Results-oriented with ability to work and deliver.
■ Excellent verbal and written communication skills in French and English.
■ Hands-on experience with downstream processing operations including filtration, chromatography, TFF, size exclusion (SEC), centrifugal partition chromatography (CPC), and mixed-mode chromatography, UF/DF, HPLC systems.
■ Hands-on experience in troubleshooting and routine instrument maintenance.
■ Previous experience in the field of extracellular vesicles from any origins.
■ Previous experience in a biotech environment.
■ Experience with scale-up and GMP manufacturing.
■ Competitive pay.
■ Highly motivating and creative working environment.
■ Challenging research and development projects.
■ Stimulating space for those who want to go beyond the expected and take risks.
■ You will build your own future.
■ Team-work - we will get there together.
■ An opportunity to make your mark at a growing start-up.
■ CDI (Contrat de Durée Indeterminée).
■ As soon as we find the right candidate.
We strongly believe AGS’ science and technology can make a difference for patients worldwide. Gene and drug therapies of tomorrow need delivery platforms that are less invasive than current alternatives, and that can deliver the therapeutic molecules safely and effectively, and that can overcome particularly stringent biological barriers to access inaccessible tissues like the gastro-intestinal tract, the brain, the choroid-retina, the lungs.
We explore and develop the potential of our technology, by putting a strong emphasis in R&D challenges, and in creating new disrupting paradigms to bypass long-standing narrow-scoped scientific assumptions.
You will have an opportunity to be a part of a highly innovative biotech, build on your skills and learn from your colleagues - but also enjoy our friendly and creative atmosphere.
If you are looking for an inspiring, challenging, ambitious, and fast-moving work environment - AGS is your place!
If you wish to apply, please write to:
Lila Drittanti - ld@ags-tx.com
We will respond to all candidates but reserve the right to invite only the selected ones for an interview (on-line and/or on-site). Please note that the selected candidates will be evaluated in a several-step process that may take a few weeks.
see all Job Openings
AGS is expanding its team and actively seeking candidates for all newly created positions.
February 2024
January 2024
